Interoperability is critical to healthcare innovation. As such, to be successful, innovators must ensure that their solutions and applications can fit with existing infrastructures of healthcare institutions and that they provide and exploit healthcare data in an appropriate and secure manner. What are the keys to designing interoperable health innovations? How to deal with data security and privacy? How to ensure the interoperability of a device or a solution even before knowing its users? How has the COVID-19 pandemic impacted ongoing barriers to interoperability? What are the standards and novel solutions facilitating interoperability?